Genotypic characterization and clinical evaluation of an influenza A/Texas/1/77 (H3N2)-like recombinant: RIT 4199
Identifieur interne : 002944 ( Main/Exploration ); précédent : 002943; suivant : 002945Genotypic characterization and clinical evaluation of an influenza A/Texas/1/77 (H3N2)-like recombinant: RIT 4199
Auteurs : G. Florent [Belgique] ; A. Hay [Royaume-Uni] ; M. Lobmann [Belgique] ; D. Jovanovic [Belgique] ; A. Dalem [Belgique]Source :
- Journal of Biological Standardization [ 0092-1157 ] ; 1979.
English descriptors
- Teeft :
Abstract
The RIT 4199 (H2N2) strain was obtained by recombination of PR/8/34 (H0N1) and A/Alaska/5/77 (H2N2) isolates. Its genetic composition was determined by RNA-RNA hybridization and by identification by gel electrophoresis of the double-stranded RNA formed.The RIT 4199 was inoculated intranasally to 27 seronegative volunteers at a dose of 107−3 EID50. The results show that it is suitable for live vaccine strain.
Url:
DOI: 10.1016/S0092-1157(79)80010-4
Affiliations:
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